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The Doctor rushes to rescue Sarah from the Brethren of Demnos while Mandragora tries to bring them under its control.
The Doctor and Sarah are drawn into the Mandragora Helix, an entity which exists among the stars and which transports the TARDIS to 15th century Italy.
The Doctor saves Giuliano from Federico's men, then they try to find Sarah, unaware Hieronymous has hypnotised her to kill the Doctor.