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The teams race from the charming, cobblestoned town of Lençóis, Bahia, to the gigantic metropolis of São Paulo, via Salvador, Rio de Janeiro, Porto Seguro and Brasília.
The race to Frutillar in southern Chile is underway. The four teams must leave the beach town of Canoa Quebrada and race through the north east region of Brazil to their second checkpoint, Lençóis, the gateway to the sprawling Chapada Diamantina National Park.
The teams reach the halfway mark, and after 16 days traversing the length of Brazil, it's time to cross the border and enter the heart of South America and three new countries.
The four new famous faces embarking on an epic 12,500 km race of a lifetime are: broadcaster Jeff Brazier and his son, Freddy; actor Kola Bokinni and his cousin, Mary Ellen; broadcaster Kelly Brook and her husband, Jeremy and Radio 2 host Scott Mills and his husband (then fiancé), Sam.
Their journey begins in Belém, Northern Brazil - the gateway to the Amazon - and will pass through five checkpoints across the length of South America, to reach the finish line in the Andes, Frutillar in Southern Chile.
Our familiar faces will say goodbye to lavish transport, smartphones and bank cards and instead must rely on their skills, cunning and ingenuity as well as the kindness of strangers.
Once again, joining the celebrities will be their nearest and dearest, providing a unique insight into people we thought we knew, through the eyes of those who know them best.