A lice outbreak forces the whole staff to be treated, causing Whoopi Goldberg to draw the wrong conclusion about the staff members' treatment hairstyles; booked guest Denis Leary calls in sick, but Staci isn't having it.

Tim Gunn stops by unexpectedly, so the staff must juggle guests. Meanwhile, Todd asks Debra Messing to film a video while channeling her old sitcom character; and Randy and Marcus pitch their invention to Mark Cuban.