On the fourth of July in New Orleans, the heat seems to trigger havoc in the streets. Holly, Nick, and Keeley arrive at a bloody scene where a woman could lose her arm after a bar fight. Then at the scene of a car accident, a first responder is assaulted while trying to tend to the victims. And as fireworks explode across the city, police officers Randy and Devin catch a teenage bike thief, and offer some tough love to get his life on track.

For the men and women on the Nightwatch, two things never stop: the calls and the questions. How can someone shoot an eight-year-old boy? How do you stop the drug epidemic in the worst parts of New Orleans? How do you get guns off the city streets? As the first responders do everything they can do save the victims of several shootings, a drug overdose, and more; and the police officers chase suspects who end up having illegal firearms, they find themselves asking these questions--and only wishing they had the answers.