The unexpected reigns in the city of New Orleans as EMS responders answer calls about a child shooting, a multiple-vehicle car accident, a reported suicide attempt, and a veteran struggling with a drug overdose. It is a night shift where things are not always what they seem.

EMS first responders keep their cool and maintain their spirits as they face a series of challenges across New Orleans, including a shooting and stabbing victim and a woman whose slot machine experience takes a bizarre turn.