Special Agents Lou DiGregorio and Belle Chen track down members of a new, more insidious mafia. Meanwhile, Special Agents Chris Serrota and Imram Juman collaborate with the NYPD to arrest the gang members responsible for the killing of Officer Randolph Holder.

Former Assistant Special Agent in Charge Don Borelli recounts uncovering a plot to bomb New York City's subway system dubbed "Operation High Rise." Special Agent-in-Charge, Counterterrorism Carlos Fernandez and NYPD Detective Frank Garcia develop relationships in Uganda that may help them stop future terrorist threats.