Espionage, crime and politics collide in modern day Mexico City. A brilliant but self-destructive CIA officer, his young and ambitious Mexican-American protegee, and the city's inspirational but secretive Mayor all struggle for power during an invasion of the city by the world's most murderous drug cartel.

Isa recruits her first "asset," a source with connections to the cartel, but stretches ethical boundaries in the process. A visitor from Wayne's past dredges up unpleasant and violent memories. Lalo risks his relationship with his wife to pursue a rape prosecution against children of the rich and powerful. And Bautista's plan for the city starts to become clearer.