MacGyver is kidnapped by enemy agents to retrieve sensitive information he stole from them. To get him to talk, they inject MacGyver with a hallucinogenic drug that will kill him in six hours, unless an antidote they have is administered.

A theft of uranium occurs at a nuclear power plant where an ex-girlfriend of MacGyver's works. She enlists his help to catch the thief which endangers hers and MacGyver's lives.