MacGyver is assigned to protect a person in the Federal Witness Protection Program. The man he is protecting wants to come out of hiding to visit his dying mother. MacGyver must protect him from the Mob and from the Feds.

MacGyver is kidnapped by enemy agents to retrieve sensitive information he stole from them. To get him to talk, they inject MacGyver with a hallucinogenic drug that will kill him in six hours, unless an antidote they have is administered.