MacGyver is somewhere in Asia to retrieve documents for his government. Soon after, a local tribe stops the train. They take all passengers hostage until the men responsible for the death of the tribal leader's son is found among the passengers.

Pete is made to believe that his Russian friend, Alexander Kharsov, is dead. When he realizes he's alive and being held in a mental hospital, he enlists MacGyver's help. Helped by Mariah, Alexander's daughter, they will try to get him out of there before he is killed.