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MacGyver is sent to Burma to retrieve a poison-filled canister from a crash site. While there, a drug lord mistakes MacGyver for a narcotics agent, forcing him into a confrontation.
A bomb goes off in a classified laboratory, sealing off the lower levels. The explosion traps two valuable scientists and unleashes an acid leak. MacGyver is called in to help the two trapped scientists escape.
MacGyver obtains a watch in Budapest that contains top secret information on microfilm. However, a young Gypsy girl steals the watch from MacGyver and he must get it back.