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MacGyver gets involved in the search for an escaped serial killer. Soon he comes to the conclusion that the killer had help from another prisoner—an even more sinister man.
While on assignment for the Phoenix Foundation to test field agents to make sure they are still in shape, MacGyver finds out he now has another agent to test: Pete. Things take a turn for the worse when MacGyver and Pete head into the wilderness where they stumble upon a wrecked plane and pictures of two dangerous drug smugglers who shot it down.
Jack receives mementos of his father from an anonymous sender. This triggers a search for Jack´s mother, who has been missing since Jack was a boy. But when he finally gets to meet her, she turns out to be a fugitive in fear of her life, and Jack´s presence only complicate things more.