MacGyver's nemesis Murdoc begs MacGyver's help to rescue his sister from his former employer. She is about to to be executed during a Halloween Party and to save her MacGyver and Murdoc have to beat a dangerous obstacle course.

MacGyver trails a friend, Billy Colton, to Africa where he witnesses the cruel slaughter of the endangered Black Rhino. When he joins the activists, hoping to prevent the poaching, Mac meets up with the men behind the scheme - Ladysmith.