Comedian and actress Rachel Dratch talks about the NYC opening of the famous Second City improv and comedy theater; cooking with chef Sophia Roe; advocate and author Chelsea Clinton discusses the inaugural Climate Disruption, Air Pollution, and Young Peoples' Health Convention.

Oncologist and author Dr. Elizabeth Comen ("ALL IN HER HEAD: The Truth and Lies Early Medicine Taught Us About Women's Bodies and Why it Matters Today"); SiriusXM Radio host and ABC News contributor Mike Muse; ABC News chief medical correspondent Dr. Jen Ashton answers viewer questions and shares wellness advice; ABC News correspondent Elizabeth Schulze reports on new data regarding the number of single women buying first-time homes; musical performance by Rhymefest ("James & Nikki: A Conversation").