Oncologist and author Dr. Elizabeth Comen ("ALL IN HER HEAD: The Truth and Lies Early Medicine Taught Us About Women's Bodies and Why it Matters Today"); SiriusXM Radio host and ABC News contributor Mike Muse; ABC News chief medical correspondent Dr. Jen Ashton answers viewer questions and shares wellness advice; ABC News correspondent Elizabeth Schulze reports on new data regarding the number of single women buying first-time homes; musical performance by Rhymefest ("James & Nikki: A Conversation").

Actor Mark Wahlberg discusses Ash Wednesday and his partnership with Hallow, a Catholic meditation and prayer app; Deals and Steals with ABC e-commerce editor Tory Johnson; a celebration of the life and legacy of musician Roy Hargrove.