Sylvia Thorton is a gun control advocate whose husband, Brandon, was shot and paralyzed while working. Someone is now threatening her and Brandon asks McCall for help, which Sylvia doesn't want.

A gun runner gets killed by arms dealer Ruger, but not before he infects some people with a fatal African disease, including one of the killers. McCall's friend, Dr Demeter, is visiting him and helps determine the virus. Mccall helps her track down the arms dealer before he infects others.