In season five, Nandor feels his familiar (and sometimes friend) Guillermo slipping away as he seems to be spending much more time with Laszlo, whose skills as a gentleman scientist are put to the test as he tries to solve the mystery of the strange and very secret changes Guillermo is going through. Nadja, suffering the effects of a previously-undiagnosed supernatural hex, reconnects with her family - or at least, a family - from the Old Country, Colin pursues the path of so many energy vampires before him by running for political office and The Guide tries to figure out where she fits in as the relative newcomer to this tightly-knit group who've known each other for centuries.