In 1958 New York, Midge Maisel's life is on track- husband, kids, and elegant Yom Kippur dinners in their Upper West Side apartment. But when her life takes a surprise turn, she has to quickly decide what else she's good at - and going from housewife to stand-up comic is a wild choice to everyone but her.

After another arrest, Midge finds herself in legal trouble, forcing her to rely on Susie's street smarts. Abe approaches Moishe with an interesting proposition. Lenny Bruce offers some unconventional inspiration for Midge's act.