7am: CDC Director Susan Monarez was fired after refusing to resign.  Her attorneys said the firing came after she refused to rubber-stamp unscientific, reckless directives in line with HHS Secretary Robert F. Kennedy Jr. In response, top officials at the agency quit, and hundreds of staffers staged a clap out in support. Plus, Federal Reserve Board Governor Lisa Cook has sued the Trump administration over their attempt to oust her. In an emergency hearing, the judge expressed concern over Trump's comments about securing a majority on the board. Neera Tanden and George Conway join "The Weekend" to discuss how this could impact everything from your finances to your physical health.

8am: President Trump revoked former Vice President Kamala Harris' Secret Service protection -- which raises even more questions about Trump leveraging the federal government against his critics -- along with his new threats to investigate Chris Christie and George Soros.  Former CIA Director John Brennan and Liz Oyer, former DOJ Pardon Attorney and Federal Public Defender, join "The Weekend" to discuss.

9am: The big shakeup could lead to a potentially competitive Senate race in Iowa. Iowa State Senator Zach Wahls is one of the Democratic candidates running to replace Ernst. He joins The Weekend to discuss what this could mean for the 2026 midterm elections.

7am: In a sign that the Trump administration is planning a repeat of what happened in Los Angeles in June, fencing was put up around a federal courthouse in downtown Chicago in preparation for protests. The Pentagon has officially greenlit using a Naval base north of the city as a staging ground to launch operations. Former House Rep. Max Rose and Maya Wiley join The Weekend to discuss President Trump's plans in Chicago and DC.

8am: The Epstein estate is set to hand over a trove of documents to lawmakers, including the infamous "birthday book," flight logs, phone records and financial transactions. Survivors met this week to pressure Congress to fully release the files. And if they don't, they plan to compile their own list of names. Maya Wiley, president and CEO of the Leadership Conference on Civil and Human Rights, joins "The Weekend" to discuss. 

9am: "It's not fair to say they're losing credibility. We're past that now," is what a judge recently said about the Department of Justice's handling of arrests during Trump's law enforcement surge in DC. The DOJ incurred a substantial amount of losses in court recently concerning deportations, tariffs, college grants, and more – though the Trump administration has already appealed many of these rulings in the hope of getting them in front of the conservative majority Supreme Court. Legal expert Andrew Weissmann and senior adviser of The Lincoln Project, Stuart Stevens, join "The Weekend" to discuss what's next.