When Mr. Drysdale is unhappy with Dr. Clyburn's treatment of his cold the Clampetts hear about it. Granny decides it's time to set up practice and enlists the rest of her family to help. She also claims a cure for the common cold.

Granny wants to learn to drive the truck but can't get used to modern day contraptions. A horse is more of what she wants and Mr. Drysdale gets her one, a professional race horse.