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Granny continues her doctoring and is especially pleased with her new batch of tonic. Dr. Clyburn is determined to get her to stop so invites her to his office to show her how modern medicine works. Granny has other ideas.
The Drysdales have temporary custody of a baby hippo and when Granny spots it she thinks it's a giant hog. She makes plans for turning into future meals while Ellie sees it as another pet.
Country music legends Lester Flatt and Earl Scruggs visit the Clampetts while Lester's "citified" wife, Gladys, heads to Mammoth Studios for a screen test directed by Jethro (at Lester's request).