Exposed as a criminal, sentenced to prison, and terminally ill due to long term kryptonite exposure, Lex Luthor escapes and assembles a supervillain team consisting of Cheetah, The Shade, Solomon Grundy, Star Sapphire, Copperhead, and Ultra-Humanite to take on the Justice League, calling themselves the Injustice Gang. The Joker also becomes part of the team, but on his own invitation. However, even with their combined power, this gang proves no match for Batman's wiles.

Jason Blood and his alter-ego Etrigan the Demon, seek the assistance of the Justice League in preventing the Philosopher's stone from falling into the hands of his ancient enemy, the sorceress Morgaine Le Fey.