A rogue Amazonian named Aresia (born in the mortal world, raised in Themyscira) gathers a small group of Luthor's former Injustice Gang including Star Sapphire, Shade, Copperhead, Solomon Grundy, and Tsukuri, and sets out to kill the world's male population, who she holds responsible for the death of her family members in a war.

The Justice League is accidentally transported to a parallel world and find the Justice Guild of America, comic book characters in the Justice League's world. While battling super villains in this other dimension, they discover that the world is just an elaborate illusion.