When the Egyptian God of Chaos inhabits a human body, he attempts to release Pure Evil into the world, thus beginning the final battle of Good vs. Evil. In order to stop him, the Librarians must decipher a series of clues within a science museum, including a mysterious warning spoken by exhibit mannequins that have come to life.

A routine artifact retrieval is anything but when the artifact grafts itself to Cassandra. Meanwhile a blizzard forces Stone and Cassandra to take shelter at a mysterious hotel that is hosting a demon convention, who want the artifact for themselves.