After Dr. Daniel Pierce suffers a traumatic injury, his father, James, and his friend Paul Haley have to make a difficult choice on whether to allow Pierce to undergo a high-risk surgery. Meanwhile, Pierce works to solve a different kind of murder case that has him questioning everything he sees and hears.

Pierce and Moretti undercover an international scandal while investigating the murders of a Bangladeshi diplomat and a Chicago reporter. Distracted by the case, Moretti struggles with preparations for her upcoming wedding to Donnie and turns to Pierce for help.