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Thatcher discovers a fresh lead of a double murder committed by Nathaniel, giving Reid cause for hope.
The serial killer - Nathaniel Dove - is hid in the Hackney Marshes, but how long can he stay out of trouble?
With Reid locked in the cells it seems that all hope is lost, but is there time for one last roll of the dice?
Returning to a dark secret they all share and to a Whitechapel terrorised by an all too familiar horror, Series Five sees the show's heroes take on a serial killer with subhuman desires, but a superhuman ability to avoid being apprehended.