When an ancient sarcophagus arrives in the laboratory at Wolfram & Hart, Fred opens a small compartment and is infected by an ancient disease that slowly begins to kill her. As Angel and Spike travel across the world in order to help her, Wesley slowly begins to realize that there may be no stopping this disease.

Angel, Spike and Gunn travel to a surprisingly unusual hell dimension to free Lindsey and find out what he knows of the Senior Partners' ultimate plans. With Illyria's army defunct and her plans averted, the gang accepts her as a dubious ally. Wesley, volunteering to be her guide and mentor, falls slowly into depression and self-destruction. Meanwhile, the Senior Partners send a new, unstoppable force, a new liaison and businessman, named Marcus Hamilton, to find Eve, and Gunn makes an important decision in an attempt to protect his friends... and save his soul.