After discovering the truth about their situation, the agents gather at the Warehouse and set out to find the person responsible for the Warehouse thefts and the attacks on their loved ones... before the responsible party endangers the world.

Unable to find where H.G. Wells hid the astrolabe, a criminally insane Artie threatens to unleash a plague upon the entire world if it is not given back to him. The Warehouse agents race against time to stop him.

While Artie tries to get back to work, Pete and Claudia investigate a radical activist from an environmental group that may be tied to an artefact... and who is killing off each member of the group that disbanded 30 years ago.

Pete and Claudia investigate a series of accidents involving earthquakes, sinkholes, and landslides, while Myka and Steve try to help Artie adjust to a Warehouse without Leena.