Clark gets a panicked phone call from Lana in which he hears her being killed. When he finds out the call is from the future, he tries to change the present, hoping to alter fate. Elsewhere, Lex tells his dad he wants to be in charge of the "resurrection serum" project.

A chemical accident at the LuthorCorp plant gives Chloe the ability to make people tell her the truth. When Lionel learns of Chloe's new power, he tries to exploit it by forcing her to uncover Clark's secrets.