A chemical accident at the LuthorCorp plant gives Chloe the ability to make people tell her the truth. When Lionel learns of Chloe's new power, he tries to exploit it by forcing her to uncover Clark's secrets.

A Kawatche grad student gets superpowers similar to Clark's when he picks up an ancient knife found in the Indian caves. Elsewhere, Lana and Chloe plan a surprise birthday party for Clark at Lex's mansion; and Lex wants to sell the Talon.