When a young girl's body is found hidden behind a wall of the Talon, Chloe begins acting weird and Lois goes on the trail of the girl's murderer, who turns out to be a serial killer who has been preying on Smallville girls for 10 years.

Clark is manipulated by Simone, who possesses a magical, hypnotic jewel that makes him love her. Meanwhile, Dr. Fine reappears in Honduras, and Lex is on his trail.