In the twenty-year future, Professor Xavier and his new X-Men fight the Sentinels and come across Polaris, who lives alone and traumatized in a destroyed Genosha. Charles learns how Genosha was destroyed and how Polaris was the only survivor. In the present, Wolverine, Forge and Shadowcat infiltrate an MRD base to investigate the Master Mold, only for the former two to get caught which led to the Wolverine-type Sentinels that the future X-Men just evaded.

The MRD starts hunting mutants without warning, forcing the X-Men to strike back. Angel joins the X-Men and tries to destroy the artificial intelligence/multi-agent system, Mastermold, accompanied by the Brotherhood who were betrayed by Magneto. However, the dystopian future still exists and Mastermold had transferred itself to a damaged Sentinel.