When a plane transporting a 10-year-old federal witness crashes, Mike determines that the accident was faked and that the boy was kidnapped. He clashes with the investigating DEA Agent, who promptly arrests him for interfering with the case. Meanwhile, Sarah fights for more authority over the SSC's future endeavors.

Mike and KITT hunt for a pilfered serum that can transform its user into a physically powerful being. Elsewhere, Sarah is overwhelmed by the all-consuming work of her new post.