Immortal warrior Blade sets up shop in Detroit with his partner Shen and investigates the vampire House of Chthon who are threatening total domination of mankind.

When Marcus keeps Krista from leaving House of Chthon, she is forced to make her way without help of Blade or Shen. With Krista unavailable to him, Blade seeks proof of Marcus' vaccine through Reverend Carlyle, link to "asher" community.