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Londo gets a visit from an old friend who seeks his help after being labelled a traitor by the Centarum. Elsewhere, Sheridan begins hallucinating after being attacked by a dead alien.
Sheridan is shocked to learn that one of the crew of the Icarus, the ill-fated science ship that exploded with his wife aboard, is alive - namely Mr. Morden. Meanwhile, a representative from the newly established Ministry of Peace visits the station to recruit personnel to the Nightwatch.
When a fatal and contagious plague threatens the Markab race with extinction, Dr. Franklin races to find a cure before more of the station's residents are killed. However, his efforts are obstructed by the Markab themselves, who believe the plague only affects the immoral.
In season two, Babylon 5 gets a controversial new leader as the station prepares to serve as the last defense against a terrifying race known as the Shadows.