When Sara and Jake investigate the murder of a prominent Soho art dealer, they quickly narrow their search to an artist who turns out to be one of an unknown number of identical brothers connected to the myth of the Witchblade. Sara seeks answers about the Witchblade from the incarcerated Madame Dominique and internet artifacts dealer, Gabriel Bowman.

A priest is brutally killed, and a young member of his congregation is the prime suspect. Despite the boy's affirmations of guilt, Sara suspects something else is at work. Investigating, she comes to believe that the boy was possessed by demons, and yet she still believes he was not the one responsible. She also fences with Father Del Toro, who has been assigned by the Vatican to investigate. Del Toro seems to know a great deal about the Witchblade as well, from its time when it was kept at the Vatican. Eventually Del Toro is revealed as the true murderer.