Walter Gilman, a college student rents a loft in a building in the New England town of Arkham. While studying interdimensional string theory at college he is haunted by nightmares of a 17th century witch and her rat with a human face. He must prevent the death of his neighbor's baby at the hands of these forces while it's possible he could become the murderer himself.

Jenifer is a tale of a modern-day Lolita who with her good looks and charm destroys the bodies and souls of all the men who crosses her path. Police officer Frank unfortunately saves this young girls life only to find out in this horrific twist that that no good deed goes unpunished.