When atrocities are linked to a 4400 with the ability to heal damaged chromosomes in utero, NTAC finds itself in a troubling international political cross fire. Elsewhere, Richard reunites with aging Korean War comrades; Diana accuses April of abusing Maia's power; and Shawn attempts to mend fences with his family.

A 4400 terrorist marks the dead Jordan Collier's birthday by planting a device within NTAC that causes all the males to turn savage, forcing a lockdown of the facility. Meanwhile, Lily suspects the 4400 Center has devious plans for Isabelle; Shawn adjusts to being a media figure; and Kyle kindles a romance.