Jane and her team are tracking several people with Neuro like abilities, but they are assassinated by a sniper just before they can be chipped. The mystery is that these people with exceptional powers are not Neuros, but the killer using a sniper rifle is. Jane and the others figure out that this entire affair began years ago when a group of high school outcasts formed a group based on a limited comic book series - The League of Five. Each one of the group were given powers like those in the comic book, but years later they seem to be turning evil, and the real Neuro who is tracking them down and killing them, knows the reason why.

Jane and the team are tracking a neuro who can make himself invisible in order to rob banks, however, once they capture him, their van melts down, almost allowing their prisoner to escape. They are mystified by this since neuros usually don't have more than one ability. On their second mission, to subdue and chip a woman, Jennifer Towne (Sonya Salomaa), who can paralyze people with her mind (and thus steal their possessions), the team is again attacked by an unseen force, nearly thwarting their mission. During this time, Jane is seeing a healer, hoping to reverse her healing powers and become 'normal again'. Is this healer who is helping Jane, really a neuro? Who is really behind these 'psychic' attacks on the team?