Suigetsu and Jugo's search for Sasuke leads them to one of Orochimaru's old hideouts where they come across his research data, which could tip the outcome of the Fourth Great War. Meanwhile, Sasuke finally sets out to settle his score with Naruto.

Tsunade leaves her post as Medic Ninja to join the other Kage in fighting Madara. Meanwhile, Sasuke goes after Itachi and learns that his brother intends on stopping Kabuto's Reanimation Jutsu.