"The fourth Great Shinobi World War has ended. But Sasuke decides to continue his solitary journey—this time to atone for his sins. Meanwhile, back at the Leaf Village, there is a growing number of missing shinobi. As Kakashi—the sixth Hokage—and the others discuss these incidents, the Leaf is attacked by a mysterious group of shinobi."

Orochimaru brings Sasuke to the Coliseum fighting ring, to lure out En Oyashiro, who may have some information regarding the Exploding Human incident. The match is called off when more Exploding Humans appear and the opportunity to meet Oyashiro seems lost. However, impressed by Sasuke's Sharingan, Oyashiro approaches him in person.