Stardate: 51652.3 - When Voyager encounters a disabled Hirogen ship with a wounded Hirogen aboard, Captain Janeway beams him aboard for treatment. Soon, the prey being hunted by this particular Hirogen, a member of Species 8472, boards Voyager, damaging it. The only immediate solution is to let the Hirogen assist the crew in tracking its prey. Finding the creature severely wounded, Captain Janeway puts it under her protection, much to the chagrin of Hirogen. Seven of Nine disobeys Janeway's order and transports the Hirogen hunter and the creature to another Hirogen ship. 

When the Hirogen capture and board Voyager, they discover that they can use the holodeck to improve the hunt by putting the prey through different situations and locations. In one simulation, Captain Janeway, Torres, Tuvok, and Seven of Nine are members of the French resistance in occupied France during World War II, with the Hirogen in roles as Nazi SS Officers. Since the Hirogen implanted the crew with subdermal transmitters, they have no idea this is on the holodeck with the safety protocols removed, and they think it's real. The Doctor in sickbay is forced to heal the injured, and it is up to him to disable the transmitters and help the crew escape.