Chief O'Brien and Dr. Bashir help the T'Lani and the Kelleruns eliminate their stockpiles of deadly biological weapons used in their centuries-long war. However, when both governments decide to make sure no technical knowledge of the weapons remains, O'Brien and Bashir must put their differences aside in the name of survival.

While surveying nearby star systems for M-Class planets, Sisko and O'Brien find themselves stranded on a previously unknown colony world where the colonists have adapted to life without advanced technology.