The doctor who treated Piper when she was sick with Oroya fever is trying to figure out how she was able to make complete recovery. As a result, accidentally gains their magical powers from their blood during a test he was conducting. Following this, he starts to use his newfound abilities in an attempt to save his dying sister. However, it doesn't take long for the doctor to go mad from having the sisters' magical powers and they have to find a way to remove them while not bringing any harm to the doctor. Meanwhile, Prue's latest assignment brings some unwanted attention from the paparazzi.

Tiring of always losing to the Charmed Ones, the Infernal Council decide to send a Genie to destroy them by granting them each a wish. As a result, the sisters soon discover that their wishes come with consequences that could be deadly. It is only after the Genie agrees to undo the wishes do things return to normal that Prue, Piper, and Phoebe are able to vanquish the dragon warlock. To thank the Genie, the sisters agree to grant him a final wish. Piper goes with Leo to meet the Elders.