Jessie, Bertram and the kids head to Bali for a family vacation, but when their private jet starts to experience difficulties, Jessie takes control of the cockpit and makes an emergency landing on a tropical island. Jessie must figure out how to get the kids home safely, all while recovering from poisonous bug bites, escaping scary monsters and tracking down Mr. Kipling.

Jessie auditions for a role in a television series and is convinced that she can talk her way into getting the part. However, it's Zuri who impresses the director. Meanwhile Emma, who Jessie left in charge at home, joins Ravi and Luke in search of what they think are carnivorous rats in the walls of their apartment.