Cesare lands in northern Italy; Catherina sends a plague-infested cloth to Alexander; Alexander taxes a newly arrived Jewish communtiy; Mattai gains the Pope's respect.

Pilgrims travel to Rome for the Jubilee year celebrations; Catherina wants to hinder the festival; Mattai's contacts destroy a Turkish fleet; Lucrezia sees a change in Frederigo; Micheletto learns his lover is a spy.