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Cesare's diplomatic mission is a success; Bianca takes her own life; Alexander and Sforza conspire to repay Gonzaga; Lucrezia travels to Naples; King Ferdinand continues the refusal of recognizing Giovanni.
Cardinal Farnese discovers Versucci's theft; Alexander calls for a Crusade; Giulia arranges an orgy for the new Cardinals; King Ferdinand learns that Lucrezia's marriage has not been consummated.
Cesare lands in northern Italy; Catherina sends a plague-infested cloth to Alexander; Alexander taxes a newly arrived Jewish communtiy; Mattai gains the Pope's respect.