In the series premiere, the White House staff is being called into work in the early hours of the morning to the news that the President of the United States has crashed his bicycle into a tree, much to the enjoyment of the press. The staff must run damage control on this and a gaffe by Deputy Chief of Staff Josh Lyman who, after provocation by Christian activist Mary Marsh on a televised debate, quips "Lady, the God you pray to is too busy being indicted for tax fraud." Also, Deputy Communications Director Sam Seaborn meets and spends an evening with Laurie (Lisa Edelstein), not knowing she is a call girl, and then accidentally tells White House Chief of Staff Leo McGarry's daughter, Mallory O'Brien, about it.

After a passenger plane is downed by Syrian forces, the President meets with the Joint Chiefs to determine the best course of action. Sam discusses his recently acquired friend with CJ, who tries to protect him. And Josh interviews a new aide for the President, Charlie. Leo takes 5 minutes to calm the President down prior to his Address to the Nation.