At a Bartlet family birthday, Penn and Teller burn an American flag in the White House, prompting a political and publicity nightmare. Aboard Air Force One, Bartlet is stricken by a paralyzing episode of MS. Josh is approached to run the Vice President's presidential campaign.

The internet press is running with a story that questions CJ's sexual orientation. CJ refuses to put out a statement, which only makes the media press harder. The effects of MS are becoming more pronounced on President Bartlet. Meanwhile, Santos declares that he will run for President but only if Josh will run his campaign.