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Mobster Jimmy Swain employs hitman Leonard Wynters, also known as "Captain Cold" for his weapon of choice, a nuclear-powered freeze ray, to eliminate his competitors and then the Flash.
Philanthropist Curtis Bonnahan, son of Derek Bonnahan, a mobster arrested by the Nightshade in the 1960s, becomes a copycat vigilante known as "The Deadly Nightshade", who employs lethal force in his crusade against crime.
Barry is cloned by Dr. Jason Brassel, who names the clone "Pollux". Upon learning he has created for the purpose of weaponization, Pollux goes on a rampage and comes into conflict with the Flash, ultimately defeating him.